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KMID : 1195620110040010052
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Clinical and Experimental Otorhinolaryngology
2011 Volume.4 No. 1 p.52 ~ p.54
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Otologic Manifestation in IgG4-Related Systemic Disease
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Cho Han-Kyu
Lee Yun-Jong
Chung Jin-Haeng
Koo Ja-Won
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Abstract
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IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-year-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.
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KEYWORD
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Immunoglobulin G, Hearing loss, Autoimmune disease
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